In a recent study published in Nature Scientific Reports, Dr. Stephanie Ramadan and her collaborators at Weill Cornell Medicine in Qatar developed a new, low-cost method to discover how human proteins interact which is a crucial step in understanding how cells work and how diseases develop. Traditional tools for detecting protein–protein interactions are slow and difficult to scale, so they updated their AVA-Seq technology to take advantage of affordable synthetic DNA and Oxford Nanopore’s long-read sequencing. This allowed them to test more than 3,000 protein pairs and identify 159 interactions, including several that are already known, confirming the method’s reliability. Because this approach works with full-length proteins and uses accessible sequencing tools like the MinION, it provides a practical way for labs of all sizes to explore the human interactome and accelerate discoveries in biology and medicine.
For the full article please see https://www.nature.com/articles/s41598-025-08549-3